November 2020 -
Volume 13 Issue 2

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Original Contributon

Small Cell Cancer of the Parotid Gland
[Abstract]
[pdf]
Hassan Almubarak, Awad Alsamghan, Mohammed Abadi Al-Saleem, Eisa Yazeed Ghazwani,
Safar Abadi Al-Saleem
DOI: 10.5742/MEJIM2020.93791


Prognostic significance of plasma bilirubin in sickle cell diseases
[Abstract]
[pdf]
Mehmet Rami Helvaci, Atilla Yalcin, Zeki Arslanoglu, Mehmet Duru, Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEJIM2020.93792


Triglycerides may be acute phase reactants which are not negatively affected by pathologic weight loss
[Abstract]
[pdf]
Mehmet Rami Helvaci, Atilla Yalcin, Orhan Ekrem Muftuoglu, Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEJIM2020.93793

Review


Parkinson's Disease: An update on Pathophysiology, Epidemiology, Diagnosis and Management
Part 5: Management Strategies
[Abstract]
[pdf]
Abdulrazak Abyad
DOI: 10.5742/MEJIM2020.93795

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Chief Editor:
Ahmad Husari MD FCCP D'ABSM
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Journal Edition - December 2020, Volume 13, Issue 3

Prognostic significance of plasma bilirubin in sickle cell diseases
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Mehmet Rami Helvaci (1)
Atilla Yalcin (1)
Zeki Arslanoglu (2)
Mehmet Duru (3)
Abdulrazak Abyad (4)
Lesley Pocock (5)

(1) Specialist of Internal Medicine, MD
(2) Specialist of Dentistry, Ph
(3) Specialist of Emergency Medicine, MD
(4) Middle-East Academy for Medicine of Aging, MD
(5) medi+WORLD International

Corresponding author:
Prof Dr Mehmet Rami Helvaci
07400, ALANYA, Turkey
Phone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received September 2020. Accepted October 2020. Published December 1, 2020.Please cite this article as: Mehmet Rami Helvaci et al. Prognostic significance of plasma bilirubin in sickle cell diseases. Middle East J Intern Med 2020; 13(3): 7-13 DOI: 10.5742/MEJIM2020.93792

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ABSTRACT

Background: Total bilirubin value of the plasma may have prognostic significance in sickle cell diseases (SCD).

Methods: All patients with the SCD were included between March 2007 and June 2016.

Results: We studied 253 patients (128 females) with a plasma bilirubin value of lower than 5.0 mg/dL and 109 patients (43 females) with a value of 5.0 mg/dL and higher. There were 31 deaths during the ten-year period (14 females with a mean age of 33.3 and 17 males with a mean age of 30.2 years, p>0.05). Although the similar mean ages (30.2 versus 31.7 years, p>0.05), male ratio (60.5% versus 49.4%, p<0.05), ileus (3.9% versus 10.0%, p<0.01), digital clubbing (6.3% versus 26.6%, p<0.001), leg ulcers (12.2% versus 20.1%, p<0.05), pulmonary hypertension (9.4% versus 23.8%, p<0.001), cirrhosis (1.5% versus 15.5%, p<0.001), chronic renal disease (CRD) (6.7% versus 12.8%, p<0.05), and exitus (4.7% versus 11.9%, p<0.001) were all higher in patients with the plasma bilirubin value of 5.0 mg/dL and higher.

Conclusion: SCD are severe inflammatory processes on vascular endothelium, particularly at the capillary level and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Total bilirubin value of the plasma may have prognostic significance due to the higher prevalence of ileus, digital clubbing, leg ulcers, pulmonary hypertension, cirrhosis, CRD, and exitus in patients with the plasma bilirubin value of 5.0 mg/dL and higher. The higher bilirubin values may either show the severity of hemolytic process initiated at birth or an advanced hepatic involvement in such cases.

Key words: Sickle cell diseases, plasma bilirubin, chronic endothelial damage, accelerated atherosclerosis, end-organ failure, metabolic syndrome, early aging

 

 

 

 

 
 


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